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KMID : 0606920220300040299
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Biomolecules & Therapeutics
2022 Volume.30 No. 4 p.299 ~ p.308
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Strategies for Manipulating T Cells in Cancer Immunotherapy
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Lee Hyang-Mi
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Abstract
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T cells are attractive targets for the development of immunotherapy to treat cancer due to their biological features, capacity of cytotoxicity, and antigen-specific binding of receptors. Novel strategies that can modulate T cell functions or receptor reactivity provide effective therapies, including checkpoint inhibitor, bispecific antibody, and adoptive transfer of T cells transduced with tumor antigen-specific receptors. T cell-based therapies have presented successful pre-clinical/clinical outcomes despite their common immune-related adverse effects. Ongoing studies will allow us to advance current T cell therapies and develop innovative personalized T cell therapies. This review summarizes immunotherapeutic approaches with a focus on T cells. Anti-cancer T cell therapies are also discussed regarding their biological perspectives, efficacy, toxicity, challenges, and opportunities.
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KEYWORD
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Cancer immunotherapy, Checkpoint inhibitor, Bispecific antibody, Adoptive T cell transfer, Tumor-specific T cells
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